Selection for the conferment of a PhD fellowship funded by the project HORIZON MSCA-2024 Doctoral Networks - Decoding and designing biomolecular systems with hybrid DNA:RNA: protein nanotechnology (BIOHYBRITE)

Position DC12 - Predictive modelling of translocation properties of nucleic acids and protein assemblies

Primary academic institution: Prof. Cristian Micheletti (SISSA)

Associated advisory team: Prof. Ulrich Keyser, UCAM

Project Description
This PhD project has a planned duration of 48 months, including the 36 months funded under the BioHYBRITE (MSCA Doctoral Networks) action plus an additional 12 months of SISSA fellowship. The project will develop and apply advanced theoretical and computational models for two purposes. First, it will characterize how the structure of nucleic acids, proteins, and their biohybrid assemblies affects their motion through nanopores. The results will then be used to design molecules with desired pore translocation properties.

The theoretical/computational project will involve close international collaborations (planned secondments) with experimental and theoretical partner groups of the BioHybrite network, through which the doctoral researcher will iteratively refine models by comparing them with experiments and, finally, formulate predictions.
 

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