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A new approach to reveal the multiple structures of RNA

22 January 2020
Combining experimental data and computer simulations to investigate dynamic molecular systems

The key of the extraordinary functionality of ribonucleic acid, better known as RNA, is a highly flexible and dynamic structure. Yet, the experimental characterisation of its different configurations is rather complex. A study conducted by SISSA and published in Nucleic Acids Research combines experimental data and molecular dynamics simulations to reconstruct the different dominant and minority structures of a single RNA fragment, providing an innovative method to study highly dynamic molecular systems.