This is the list of publications of our Laboratory in 2012

• Brain delivery of AAV9 expressing an anti-PrP monovalent antibody delays prion disease in mice.

Moda F, Vimercati C, Campagnani I, Ruggerone M, Giaccone G, Morbin M, Zentilin L, Giacca M, Zucca I, Legname G, Tagliavini F.

Prion. 2012 Sep-Oct;6(4):383-90. doi: 10.4161/pri.20197. Epub 2012 Jul 30. 

• Mapping the prion protein distribution in marsupials: insights from comparing opossum with mouse CNS.

Poggiolini I, Legname G.

PLoS One. 2012;7(11):e50370. doi: 10.1371/journal.pone.0050370. Epub 2012 Nov 29. 

• Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism.

Biljan I, Giachin G, Ilc G, Zhukov I, Plavec J, Legname G.

Biochem J. 2012 Sep 1;446(2):243-51. 

• Dominant-negative effects in prion diseases: insights from molecular dynamics simulations on mouse prion protein chimeras.

Cong X, Bongarzone S, Giachin G, Rossetti G, Carloni P, Legname G.

J Biomol Struct Dyn. 2012 Aug 30. [Epub ahead of print]. 

• Effects of the Pathological Q212P Mutation on Human Prion Protein Non-Octarepeat Copper-Binding Site.

D'Angelo P, Della Longa S, Arcovito A, Mancini G, Zitolo A, Chillemi G, Giachin G, Legname G, Benetti F.

Biochemistry. 2012 Aug 7;51(31):6068-79. 

• The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells.

Didonna A, Sussman J, Benetti F, Legname G.

Prion. 2012 Jul 1;6(3). [Epub ahead of print]

• Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits.

Benetti F, Gustincich S, Legname G.

Expert Opin Drug Discov. 2012 Mar;7(3):245-59.

• Early structural features in mammalian prion conformation conversion.

Legname G

Prion. 2012 Jan 1;6(1). [Epub ahead of print].

• A novel expression system for production of soluble prion proteins in E. coli.

Abskharon RN, Ramboarina S, El Hassan H, Gad W, Apostol MI, Giachin G, Legname G, Steyaert J, Messens J, Soror SH, Wohlkonig A.

Microb Cell Fact. 2012 Jan 10;11:6.

• A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation.

Chiriano G, De Simone A, Mancini F, Perez DI, Cavalli A, Bolognesi ML, Legname G, Martinez A, Andrisano V, Carloni P, Roberti M.

Eur J Med Chem. 2012 Feb;48:206-13. Epub 2011 Dec 16.