This is the list of publications of the Prion Biology Laboratory at SISSA in 2010 

• Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein.

Abskharon RN, Soror SH, Pardon E, El Hassan H, Legname G, Steyaert J, Wohlkonig A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1644-6. Epub 2010 Nov 26.

• Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound.

Bongarzone S, Tran HN, Cavalli A, Roberti M, Carloni P, Legname G, Bolognesi ML.

J Med Chem. 2010 Nov 25;53(22):8197-201. Epub 2010 Nov 3.

• Oriented immobilization of prion protein demonstrated via precise interfacial nanostructure measurements.

Sanavio B, Scaini D, Grunwald C, Legname G, Scoles G, Casalis L.

ACS Nano. 2010 Nov 23;4(11):6607-16. Epub 2010 Oct 19.

• Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study.

Sousa F, Mandal S, Garrovo C, Astolfo A, Bonifacio A, Latawiec D, Menk RH, Arfelli F, Huewel S, Legname G, Galla HJ, Krol S.

Nanoscale. 2010 Dec 1;2(12):2826-34. Epub 2010 Oct 15.

• De novo prions.

Benetti F, Geschwind MD, Legname G.

F1000 Biol Rep. 2010 Jun 23;2. pii: 46.

• A novel class of potential prion drugs: preliminary in vitro and in vivo data for multilayer coated gold nanoparticles.

Ai Tran HN, Sousa F, Moda F, Mandal S, Chanana M, Vimercati C, Morbin M, Krol S, Tagliavini F, Legname G.

Nanoscale. 2010 Dec 1;2(12):2724-32. Epub 2010 Oct 14.

• Structural facets of disease-linked human prion protein mutants: a molecular dynamic study.

Rossetti G, Giachin G, Legname G, Carloni P.

Proteins. 2010 Dec;78(16):3270-80. doi: 10.1002/prot.22834.

• Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells.

Didonna A, Legname G.

Mol Neurodegener. 2010 Aug 9;5(1):29.

• NMR structure of the human prion protein with the pathological Q212P mutation reveals unique structural features.

Ilc G, Giachin G, Jaremko M, Jaremko Ł, Benetti F, Plavec J, Zhukov I, Legname G.

PLoS One. 2010 Jul 22;5(7):e11715.

• Discovery of a class of diketopiperazines as antiprion compounds.

Bolognesi ML, Ai Tran HN, Staderini M, Monaco A, López-Cobeñas A, Bongarzone S, Biarnés X, López-Alvarado P, Cabezas N, Caramelli M, Carloni P, Menéndez JC, Legname G.

ChemMedChem. 2010 Aug 2;5(8):1324-34.

• Neurodevelopmental expression and localization of the cellular prion protein in the central nervous system of the mouse.

Benvegnù S, Poggiolini I, Legname G.

J Comp Neurol. 2010 Jun 1;518(11):1879-91.PMID: 20394048 [PubMed - in process]

• Modulation of alpha-synuclein aggregation by dopamine analogs.

Latawiec D, Herrera F, Bek A, Losasso V, Candotti M, Benetti F, Carlino E, Kranjc A, Lazzarino M, Gustincich S, Carloni P, Legname G.

PLoS One. 2010 Feb 16;5(2):e9234.PMID: 20169066

• Gene expression profiling to identify druggable targets in prion diseases.

Benetti F, Gasperini L, Zampieri M, Legname G.

Expert Opin. Drug Discov. 2010 Feb 5(2): 177-202.

• Synthesis and evaluation of a library of 2,5-bisdiamino-benzoquinone derivatives as probes to modulate protein-protein interactions in prions.

Tran HN, Bongarzone S, Carloni P, Legname G, Bolognesi ML.

Bioorg Med Chem Lett. 2010 Feb 4. [Epub ahead of print]PMID: 20172720

• Protease-sensitive synthetic prions.

Colby DW, Wain R, Baskakov IV, Legname G, Palmer CG, Nguyen HO, Lemus A, Cohen FE, DeArmond SJ, Prusiner SB.

PLoS Pathog. 2010 Jan 22;6(1):e1000736.PMID: 20107515