Prion Biology Laboratory

This is the list of publications of our Laboratory in 2011

• 
  A system-level approach for deciphering the transcriptional response to prion infection.

Zampieri M, Legname G, Segrè D, Altafini C.

Bioinformatics. 2011 Dec 15;27(24):3407-14. Epub 2011 Oct 20.

• Spontaneous generation of anchorless prions in transgenic mice.

Stöhr J, Watts JC, Legname G, Oehler A, Lemus A, Nguyen HO, Sussman J, Wille H, DeArmond SJ, Prusiner SB, Giles K.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21223-8. Epub 2011 Dec 12.

• Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation.

Biljan I, Ilc G, Giachin G, Raspadori A, Zhukov I, Plavec J, Legname G.

J Mol Biol. 2011 Sep 30;412(4):660-73. Epub 2011 Aug 4.

• Common Structural Traits across Pathogenic Mutants of the Human Prion Protein and Their Implications for Familial Prion Diseases.

Rossetti G, Cong X, Caliandro R, Legname G, Carloni P.

J Mol Biol. 2011 Aug 19;411(3):700-12. Epub 2011 Jun 12.

• Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes.

Abskharon RN, Soror SH, Pardon E, El Hassan H, Legname G, Steyaert J, Wohlkonig A.

Protein Eng Des Sel. 2011 May 1. [Epub ahead of print]

• Hybrid lipoic acid derivatives to attack prion disease on multiple fronts.

Bongarzone S, Tran HN, Cavalli A, Roberti M, Rosini M, Carloni P, Legname G, Bolognesi ML.

ChemMedChem. 2011 Apr 4;6(4):601-5. doi: 10.1002/cmdc.201100072. Epub 2011 Mar 15.

• Developmental influence of the cellular prion protein on the gene expression profile in mouse hippocampus.

Benvegnù S, Roncaglia P, Agostini F, Casalone C, Corona C, Gustincich S, Legname G.

Physiol Genomics. 2011 Jun 28;43(12):711-25. Epub 2011 Mar 15.

• Infrared Microspectroscopy: A Multiple-Screening Platform for Investigating Single-Cell Biochemical Perturbations upon Prion Infection

Alessandro Didonna, Lisa Vaccari, Alpan Bek, Giuseppe Legname.

ACS Chemical Neuroscience 2011 2 (3), 160-174

• Aged PrP null mice show defective processing of neuregulins in the peripheral nervous system.

Benvegnù S, Gasperini L, Legname G.

Mol Cell Neurosci. 2011 Feb 17. [Epub ahead of print]

• Epitope mapping of a PrP(Sc)-specific monoclonal antibody: identification of a novel C-terminally truncated prion fragment.

Kosmač M, Koren S, Giachin G, Stoilova T, Gennaro R, Legname G, Serbec VČ.

Mol Immunol. 2011 Feb;48(5):746-50. Epub 2010 Dec 19.

• Compact conformations of α-synuclein induced by alcohols and copper.
  

Natalello A, Benetti F, Doglia SM, Legname G, Grandori R.

Proteins. 2011 Feb;79(2):611-21.