Prion Biology Laboratory

This is the list of publications of the Prion Biology Laboratory at SISSA in 2009

• Continuous quinacrine treatment results in the formation of drug-resistant prions.

 Ghaemmaghami S, Ahn M, Lessard P, Giles K, Legname G, DeArmond SJ, Prusiner SB.

PLoS Pathog. 2009 Nov;5(11):e1000673. Epub 2009 Nov 26.

• Design and construction of diverse mammalian prion strains.

Colby DW, Giles K, Legname G, Wille H, Baskakov IV, DeArmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20417-22. Epub 2009 Nov 13.PMID: 19915150

• De novo mammalian prion synthesis.

Benetti F, Legname G.

Prion. 2009 Oct;3(4):213-9. Epub 2009 Oct 26.

• Structural insights into alternate aggregated prion protein forms.

Polano M, Bek A, Benetti F, Lazzarino M, Legname G.

J Mol Biol. 2009 Nov 13;393(5):1033-42. Epub 2009 Aug 28.

• Prion proteins with pathogenic and protective mutations show similar structure and dynamics.

Bae SH, Legname G, Serban A, Prusiner SB, Wright PE, Dyson HJ.

Biochemistry. 2009 Sep 1;48(34):8120-8.

• Docking ligands on protein surfaces. The case study of prion protein.
  

Kranjc A, Bongarzone S, Rossetti G, Biarnés X, Cavalli A, Bolognesi ML, Roberti M,
Legname G, Carloni P.

J Chem Theory Comput., 2009 Aug 14;5(9):2565-73.

• Investigating the conformational stability of prion strains through a kinetic replication model. 

Zampieri M, Legname G, Altafini C.

PLoS Comput Biol. 2009 Jul;5(7):e1000420. Epub 2009 Jul 3.

• Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration.

Benvegnù S, Franciotta D, Sussman J, Bachi A, Zardini E, Torreri P, Govaerts C, Pizzo S, Legname G.

PLoS One. 2009 Jun 18;4(6):e5968. Erratum in: PLoS One. 2009;4(8).

• Development of antibody fragments for immunotherapy of prion diseases.

Campana V, Zentilin L, Mirabile I, Kranjc A, Casanova P, Giacca M, Prusiner SB, Legname G, Zurzolo C

Biochem J. 2009 Mar 15;418(3):507-15.