SISSA -- PhD in Structural and Functional Genomics
Course Announcement,  Fall 2005
 

Mathematical Methods in Systems Biology


Lecturer:  Claudio Altafini 
  altafini@sissa.it
  ~altafini

Format

5 lectures, (1h30 each)

Schedule

9 November 15:00-17:00; 2 December 15:00-17:00; 5 December 16:00-18:00; 6 December 16:00-17:00; 7 December 14:00-17:00; all in Aula Magna

Tentative Course Outline

Pathways as Dynamical Systems
  1. Dynamical Pathways as ODEs
  2. Elementary modules from reaction kinetics
  3. Qualitative behavior: steady state, stability and multistability
  4. Feedback regulation: examples
  5. Parameter fitting: linear regression
Inferring Regulatory Networks
  1. Aggregating data: clustering algorithms
  2. Reverse engineering via "system identification" techniques
  3. Other methods: looking for a "core regulatory kernel"